Mukormikosis Rino-Orbito-Serebral pada Diabetes Melitus

<p>Mukormikosis rino-orbito-serebral (ROS) adalah penyakit angioinvasif akibat infeksi jamur Mucorales yang sering ditemukan pada pasien diabetes melitus (DM). Penyakit ini memiliki gambaran khas jaringan nekrotik kehitaman disebut eschar, sehingga juga “jamur hitam”. Tingkat mortalitas tinggi terutama jika diagnosis dan tata laksana terlambat. Patogenesis mukormikosis ROS DM antara lain: interaksi reseptor sel epitel dengan protein jamur, kadar besi bebas dalam darah, penurunan imunitas seluler. Diagnosis berdasarkan klinis faktor risiko, identifikasi pencitraan. Pemeriksaan histopatologis dari biopsi dapat dikonfirmasi hasil kultur. Tata penderita meliputi kombinasi debridemen, pemberian antijamur, mengatasi kondisi hiperglikemia.</p><p> </p><p>Rhino-orbital-cerebral mucormycosis (ROCM) is an angioinvasive disease caused by fungal infection; it common in mellitus (DM) patients. The has a characteristic feature of black necrotic appearance called thus also as “black fungus” infection.<br />The mortality rate this high, especially delayed and treatment. pathogenesis ROCM diabetic patients includes the interaction epithelial cell receptors with proteins, free iron blood levels, decreased cellular immunity. based on<br />clinical features, supporting risk factors, fungus identification, imaging. Histopathological examination on biopsy tissue confirmed culture can establish diagnosis. Management combination surgical debridement, antifungals, glycemia control.</p>